Buformin hydrochloride

Research use only, not for human use.

Buformin hydrochloride is a potent AMPK activator,an oral antidiabetic drug of the biguanide class.

Buformin hydrochloride is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointestinal tract increases insulin sensitivity and glucose uptake into cells and inhibits synthesis of glucose by the liver. Biguanides may antagonize the action of glucagon, thus reducing fasting glucose levels.

Cell Viability Assay Cell Line:ErbB-2-overexpressing SKBR3 and BT474 cells Concentration:0 μM, 1 μM, 3 μM, 10 μM, 30 μM, 100 μM, 300 μM, 1, 3, or 10 mM Incubation Time:5 days Result:Reduced cell viability in erbB-2-overexpressing breast cells.Cell Cycle Analysis Cell Line:ErbB-2-overexpressing SKBR3 and BT474 cells Concentration:0.5 mM; 1 mM; 3 mM Incubation Time:48 hours Result:Increased cells arresting in G0/G1 phase.Western Blot Analysis Cell Line:ErbB-2-overexpressing SKBR3 and BT474 cells Concentration:0 mM, 0.1 mM, 0.3 mM, 1 mM, or 3 mM Incubation Time:24 hours Result:Decreased p-AMPK, p-p706S, p-ERK1/2 expression in a concentration-dependent manner.

Animal Model:Female MMTV-erbB-2 transgenic mice Dosage:7.6 mmol/kg Administration:Oral administation; 7 days Result:Inhibited mammary syngeneic tumor growth in MMTV-erbB-2 transgenic mice.

NSC 528218 | NSC-528218 | NSC528218

Membrane Transporter/Ion Channel

AMPK

AMPK

——

——

1190-53-0

193.68

C6H16ClN5

>98% (HPLC)

DMSO:Soluble

CCCCN=C(N)N=C(N)N.Cl

——

(-20℃)

With Ice Pack

≥ 2 years